Drug Design (PHCM081)
Offered By:
Pharmacy and Biotechnology Faculty
Description
The course allows the student to get introduced to non-computational and computational methods in drug design, pharmacophores, the relevance of and methods involved in the improvement of binding interactions between drug and its targets (finding lead compounds, the role of combinatorial chemistry, drug actions at receptors, improvement of pharmacokinetic properties of drugs. Computer-aided drug design and molecular modeling. Relevance of drug metabolism regarding the affinity of molecules to pharmacological receptors, transporters and metabolizing enzymes in sequential pathways including examples for active metabolites and prodrugs.In the computer course the students will get acquainted with methods used to correlate physicochemical properties with biological activity and the basics of computer-based methods of 3D-QSAR in order to understand their relevance for lead identification, modification and optimization. Practical lab course deals with qualitative and quantitative analysis of drug substances, degradation products and metabolites in complex mixtures (like drug formulations, biological fluids), the identification and quantification of molecules in toxicological material as well as biological fluids in therapeutic drug monitoring.
Herein, we acknowledge, the Chemical Computing Group http://www.chemcomp.com/ for providing a teaching license for the MOE program adopted in the practical part of the Drug Design Course.