Neurological disorders affect people at all ages. Young patients are often hidden away, while increasing life expectancy results in a rising incidence of Alzheimer’s disease and other neurodegenerative disorders. Injury of the central nervous system, through trauma or diseases are further contributors.
This research cluster aims to understand the molecular function and dysfunction of disease-related receptors and nervous signaling systems. The approach is twofold – in vitro experiments allow study of one candidate protein or receptor in isolation. Animal models give information on the effect of any disease on the living organism and allows the evaluation of novel therapeutics. Both methods complement each other.
Focus in thei cluster is on ion channel-associated disioders such as glycine- and acetylcholine receptor-associated disorders, mood disorders (serotonin 5-HT3 receptors), and also Alzheimer’s disease and animal models of Parkison’s disease. In addition to pathomechanisms, this cluster also is involved in the development of new therapies.
Participating Research Groups:
C.1 Neurodegenerative Diseases
Neurodegenerative Diseases and Neuroprotection
GUC Alzheimer’s Disease Unit (GADU)
D.1 Clinical Biochemistry
D.2 Neurobiochemistry/Ion Channel Pharmacology